First, the editor solicited the review, and that’s who you’re giving it to. There are many kinds of conflicts. Du reichst deinen Artikel ein, indem du dafür einen Online-Account beim Journal oder dem Publisher erstellst. They overstate some difficulties of peer-review (No-one looks at every data value? So können die Begutachtenden durch ihre Anmerkungen wesentlich zur Verbesserung deines Artikels beitragen. Du musst also mit längeren Bearbeitungszeiten rechnen. In either case, the posterior mean value of x remains 2/3 (contrary to Efron 2013b, but in accord with the correction in Efron 2013a). I believe this is a very reasonable and testable hypothesis. März 2020. Page 5: since data on mate choice come from other studies is it so necessary to report a detailed description of methods for this section? This will effectively guarantee a correct prediction rate above chance. And Efron’s (2013a) result is consistent with Pr(x = 1) having a uniform prior. However, this is a good example where this cannot be done easily, and Amrhein et al. Note, if the prior for Pr(x = 1) is specified as 0.5, or dunif(0,1), or dbeta(0.5, 0.5), the posterior probability that these twins are identical is 2/3 in all cases. More detail here would be welcome (and also in Conclusion); in subsequent paragraph about Pipit foraging behavior and specific relationship to understory vegetation at varying heights could be incorporated into this discussion. Scaling these weights so they sum to one (Burnham and Anderson 2002), gives a weight of 2/3 for identical twins and 1/3 for fraternal twins. Nevertheless, a prior that specifies Pr(x = 1) = 0.5 does indicate uncertainty about whether this particular set of twins is identical (but certainty in the population level frequency of twins). Please take care to be friendly, and to use polite language, but you don’t want to give a manuscript a more positive review than you think it deserves. This study, which was originally designed to identify axonal chemorepellents, actually provided a previously unknown role for H1, as well as other novel and thought provoking results. There are a number of issues with the methods and analysis that need to be clarified/addressed however; furthermore, some of the conclusions overreach the data collected, while other important results are given less emphasis that they warrant. By continuing to browse the site, you are agreeing to our use of cookies. Nature. Nach der Einreichung entscheiden die Herausgebenden des Journals, ob sich dein Paper generell als Publikation eignet. In fact, a quick spot check seems to confirm this suspicion: correlating the time series separately for each channel from the Receiver in pair 1 with those from the Receiver in pair 18 reveals 131 significant (p‹0.05, Bonferroni corrected) out of 196 (14x14 channels) correlations… One could perhaps argue that this is not surprising because both these pairs had been exposed to identical stimulus protocols: one minute of initial silence and only one signal period (see point 6). Math Soc. Model Selection and Multi-model Inference: a Practical Information-theoretic Approach. Remove the repetition. A conflict also exists if you are friends or a direct competitor of an author. To check if this is true, I quickly generated random data and used the analysis procedure as laid out above (see MATLAB code below). The manuscript is certainly well written and attractive, but I have some major concerns on the data analyses that prevent me to endorse its acceptance at the present stage. Can this be resolved? The authors further argue that the between-isolate differences in behavior arise from a Founder's effect, at least in the differences in locomotor behavior between the Paris lines CS_TP and CS_JC. Does the data properly support the thesis? Eliminate typos, missing words, and grammatical errors. Can versatile and complicated pulse protocols be applied? Indeed, when the assumption of common slopes is violated (as in Because when the authors respond to revisions, they may be dealing with conflicting “orders” from reviewers. With this zebrafish model, they were able to confirm that an inhibitor of E3 ligases and of the Nedd8-E1 activating suppressed the motor axon anomalies, as predicted by the effect of mutations in S. pombe on the phenotypes of the UBA1 overexpression. Bevor du dein Paper einreichst, suchst du ein hochbewertetes Journal, das zum Thema deines Papers passt. This is further corroborated by the fact that when using stimulus labels that are chosen completely at random (i.e. Therefore, the weight of evidence in favour of identical twins is twice that of fraternal twins. between treatment and species. Many similar sentiments, but really emphasizes the point of kindness and constructive criticism when it’s clear the lead author is a student: https://smallpondscience.com/2017/04/24/an-introduction-to-writing-a-peer-review/. We don’t know the true state x, and we don’t know the prior (except in the case where we use the doctor’s knowledge that Pr(x = 1) = 1/3). Please try again, Email address not valid, please try again. Unfortunately, accurate measurement of INaL is a time consuming and technical challenge because of its extra-small density. I was wondering if the authors could develop a bit more the general concept that seems to indicate that in disease (and in particular in cancer) the expression and levels of miRNAs are in general downregulated. How large of an advance in the field does the manuscript make? Other journals ask you to not make a recommendation. In the case where the prior distribution for pr_ident_twins is uniform or beta, the posterior distributions remain broad, but they differ depending on the prior (as they should – different priors lead to different posteriors 4). A note explaining this would be useful. To do so, they can enter as random factor the interaction Is there a work the author has neglected to cite? Some journals might set limits. That was probably done during the formatting and editing step of the paper. The first is a short 1-3 sentence summary of what the reviewer thinks the paper says, with an overall opinion about quality and shortcomings. Pg 6, C2: in the paragraph immediately below the ‘grep()’ for “RAG1”, two consecutive sentences begin with “However”. A number of examples illustrate the scope of the package, something that is fully expanded upon in the two appendices, which are a welcome addition to the paper. There are a number of questions left hanging: is the purpose to understand communicator experiences ‐ in which case why focus on perceptions of audiences? My final point has reference to the potential that this data set has, particularly if it is extended and developed. Last Updated: October 30, 2019 Wenn du Teile deiner Masterarbeit oder Dissertation publizieren möchtest und generell eine wissenschaftliche Karriere anstrebst, dann musst du dich mit Peer-Review Verfahrenauskennen. Priska Flandorfer. This guide outlines…, A Reviewer’s Quick Guide to Assessing Open Datasets There is a growing appreciation of the importance of data storage, maintenance and sharing…, What is Open Peer Review, and how is it different from other review models? Another excellent resource is this EOS guide (with step by step instructions starting from when you receive the request): https://eos.org/project-updates/a-quick-guide-to-writing-a-solid-peer-review. Instead, Efron combines different pieces of expert knowledge from the doctor and genetics using Bayes’ theorem.”. Has been the automated dispensing system tested? We see that the answer depends on the prior probability that the twins are identical, Pr(x=1). The only comment is that resting membrane potential seems to be somewhat variable. P. 8: discussion of classification of habitat types in ASF is certainly interesting, but could be made much more succinct in keeping with focus of this paper. Here, the awesome power of the model organism community comes into the picture as there is a zebrafish model of spinal muscular atrophy. Perhaps rephrase to indicate that the value and sense of doing these trials is open to question, with attendant ethical implications, or softer wording to that effect. would be helpful – and especially why these and other aspects render the Pipit a good indicator species/proxy for habitat condition. Based on the excessive Bayes Factor of 390,625 it is clear that the authors assumed a chance level of 50% on their binomial test. For each subject the PD values across the 20 trials were converted to z-scores. Given this phenotype, the authors then went to work and using the power of the synthetic genetic array approach pioneered by Boone and colleagues made a systematic set of double mutants combining the human expressed UBA1 gene with knockout alleles of a plurality of S. pombe genes. Authors entered the wikiHow marks an article as reader-approved once it receives enough positive feedback. Questions thus are: does this automated equipment allow to the analysis of the frequency-, time-, and voltage-dependent effects of drugs? Maybe the authors could refer to the already published methods and only give a brief additional description. The sign of the mean z-score for each stimulus was used to make predictions. Here are some guidelines and a step by step guide to help you conduct your peer review. wikiHow's Content Management Team carefully monitors the work from our editorial staff to ensure that each article is backed by trusted research and meets our high quality standards. Although perhaps a sensitive issue, it might have been helpful if the authors had been able to obtain samples of cells (or their mRNA) from the original authors for simultaneous analysis. Reserve “we” for reference to the authors and use something else (“a user” perhaps) for the other instances. While the data are biased, the claim by Amrheim et al. Decoding mental states from brain activity is typically extremely noisy and hardly affords accuracies at the level seen here. are using the data to estimate the population frequency of identical twins rather than the state of this particular set of twins. After having performed these additional analyses I am inclined to agree. What efforts have the authors made to ensure that they are not speaking to a single, small, sub-community in the much wider category of science communicators? INaL is a small current component generated by a fraction of Nav1.5 channels that instead to entering in the inactivated state, rapidly reopened in a burst mode. Conventional classification analysis report what data features (usual columns in the data matrix) and what observations (usual rows) were used. Anything could be a feature but typically this might be the different EEG channels or fMRI voxels etc. If you still need help with your Facebook account password, please click here. Erfahre binnen 10 Minuten, ob du ungewollt ein Plagiat erzeugt hast. As such this article represents an excellent and elegant bioinformatics genome-wide study which will almost certainly influence our thinking about protein aggregation and evolution. -Even if a paper is really bad, please find something you can genuinely praise. If you manage peer review at one or more academic journals, you’re likely always on the lookout for ways to speed up your process. A key feature that is repeated throughout is the need for reproducibility of science workflows and taxize provides a means to achieve this within the R software ecosystem for taxonomic search. Third, we find it at least debatable whether a prior can be called an uninformative prior if it has a fixed value of 0.5 given without any measurement of uncertainty.”. Because, well, the authors will probably think it’s you anyway. Denn je mehr hochwertige Publikationen du vorweisen kannst, desto besser ist das für deine Karriere in der Wissenschaft. Standardization of maturation methods of ventricular myocytes derived from hiPS will be a big achievement for cardiac cellular electrophysiology which was obliged for years to the imprecise extrapolation of data obtained from a combination of several species none of which was representative of human electrophysiology. Die Begutachtung ist nicht objektiv, wenn die Reviewer in ihrer Denkschule zu sehr verankert sind und keine neuen Ideen zulassen. If you were being particularly ginger with your words in the main review, and you have more unvarnished thoughts that you’d like to be sure the editor hears, please put them here! Idem the lung fibroblasts. If you’re wondering, “Here’s what I think about the manuscript, but what should I say and how should I say it?” then this is useful. Bei einem Peer-Review wird dein Paper von unabhängigen Begutachtenden aus demselben Fachgebiet, also von Peers, bewertet. -Read the instructions. The example concerns a woman who is carrying twins, both male (as determined by sonogram and we ignore the possibility that gender has been observed incorrectly). While some folks complain that reviews are unnecessarily acerbic, on the editorial end I’ve had bigger challenges parsing the criticisms of reviewers who are trying to be gentle with reviewers and I’m trying to understand exactly how important matters are to the reviewer. It is a bit confusing considering the particular nomenclature used for miRNAs. interaction (as they did for other non significant terms, see top left of the same page 7). Also, it increases the probability that the reviewer will listen to what you have to say. raises some interesting points that seem worth discussing, but it makes important errors in analysis and interpretation, and misrepresents the results of Efron (2013a). If it was supplied, do you think the argument would be stronger? For example, don't write “The author has never read a work of feminist art history, obviously.” Instead, you can write, “The author's summary of feminist art history is not as detailed as it should be.”. other sites in the US), or that it is redeveloped as a case study of a particular local professional community. Here is WinBUGS code for the case using Pr(x = 1) = 0.5. If some missing information constrains what you can learn, then explain this, and leave it to the editor to decide what the authors need to do. See, The reason for this is presumably that the authors used non-independent data for training and testing. What is the role of the curator or data scientist in all of this? Minor points to consider in subsequent versions: The authors describe their attempt to reproduce a study in which it was claimed that mild acid treatment was sufficient to reprogramme postnatal splenocytes from a mouse expressing GFP in the oct4 locus to pluripotent stem cells.
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